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Program Announcements (PAs) & Requests for Applications (RFAs)



The ODS coordinates and collaborates on funding initiatives across NIH and with other agencies through mechanisms such as Requests for Applications (RFAs) and Program Announcements (PAs).
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Fiscal Year 2009

  • Dietary Supplement Research Centers: Botanicals (P50)external link icon
    Release Date: January 29, 2009
    Application Receipt Date: January 29, 2009
    ODS, NCCAM and NCI invite new and renewal applications to support research centers which will (1) promote collaborative integrated interdisciplinary study of botanicals, particularly those found as ingredients in dietary supplements and (2) conduct research of high potential for being translated into practical benefits for human health. This initiative is intended to advance the spectrum of botanical research activities, ranging from plant identification and characterization to early phase clinical studies. Preclinical research that will inform future clinical studies is encouraged as the primary research focus of this program.

Fiscal Year 2007

  • International Research Scientist Development Award (K01)external link icon
    Release Date: October 25, 2006
    Other Important Dates: See announcement for details
    This award provides U.S. postdoctoral biomedical scientists, in the early stages of their careers, with a period of mentored research as part of a strong, established collaboration between a U.S. sponsor and a leading developing country scientist at an internationally recognized research institution. It is expected that, following this experience, the candidate will be able to pursue an independent and productive international research career, involving ongoing collaboration with developing country scientists on research relevant to stemming a major global health problem.

Fiscal Year 2006

  • Independent Scientist Award (K02)external link icon
    Release Date: August 15, 2006
    Other Important Dates: See announcement for details
    The Independent Scientist Award (K02) is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. It provides three, four, or five years of salary support and “protected time” for newly independent scientists (see IC provisions) who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers.
  • Networks and Pathways Collaborative Research Projects (R01)external link icon
    Release Date: August 10, 2006
    Other Important Dates: See announcement for details
    This announcement solicits applications for research project grants that will leverage and complement the ongoing technology development being pursued in the National Technology Centers for Networks and Pathways (TCNPs), a program of the NIH Roadmap for Medical Research. These collaborative projects should focus either on addressing a challenging biological problem using the technology developed in one or more of the TCNPs, or on the development of technology that will complement that which is being developed in the centers. Applicants may request support for their own work as well as supplemental support for components pursued in the participating TCNP.
  • Dissemination and Implementation Research in Health (R03) external link icon
    Release Date: August 10, 2006
    Other Important Dates: See announcement for details
    This funding announcement opportunity (FOA) encourages investigators to submit research grant applications that will identify, develop, and refine effective and efficient methods, structures, and strategies that test models to disseminate and implement research-tested health behavior change interventions and evidence-based prevention, early detection, diagnostic, treatment, and quality of life improvement services into public health and clinical practice settings.
  • Dissemination and Implementation Research in Health (R21)external link icon
    Release Date: August 10, 2006
    Other Important Dates: See announcement for details
    This Funding Opportunity Announcement (FOA) encourages investigators to submit research grant applications that will identify, develop, and refine effective and efficient methods, structures, and strategies that test models to disseminate and implement research-tested health behavior change interventions and evidence-based prevention, early detection, diagnostic, treatment, and quality of life improvement services into public health and clinical practice settings. This FOA will use the NIH Exploratory/Developmental Research Grant Award (R21) mechanism and runs in parallel with an FOA of identical scientific scope (PAR-06-520) that will utilize the small research project grant (R03) mechanism.
  • Mentored Clinical Scientist Research Career Development Award (K08)external link icon
    Release Date: August 7, 2006
    Other Important Dates: See announcement for details
    The Mentored Clinical Scientist Research Career Development Award (K08) represents the continuation of a long-standing NIH program that provides support and “protected time” to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.
  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Researchexternal link icon
    Release Date: July 21, 2006
    Other Important Dates: See announcement for details
    The primary objective of this funding opportunity announcement is to help ensure that diverse pools of highly trained scientists will be available in appropriate research areas to carry out the Nation’s biomedical, behavioral, health services, or clinical research agenda. This initiative seeks to improve the diversity of the health-related research workforce by supporting the training of predoctoral students from groups that have been shown to be underrepresented.
  • Assay Development for High Throughput Molecular Screening (R21)external link icon
    Release Date: July 13, 2006
    Application Receipt Date: September 22, 2006
    The overall goal of the initiative is to facilitate the creation of a public database of biological information about small molecule chemical structures, which then seeds the further development of small molecule pharmacological tools for biological research. Other efforts within the Initiative also supporting this objective include the development of HTS-related technologies, Informatic applications and Preclinical tools.
  • Collaborative Research on Tinnitus (R01)external link icon
    Release Date: July 10, 2006
    Application Receipt Date: November 29, 2006
    The purpose of this RFA is to support collaborative research teams to investigate tinnitus. Tinnitus is the perception of sound in the absence of an environmental acoustic stimulus. Though research is providing more evidence for the causes and treatments of tinnitus, there is no real understanding of the biological bases of tinnitus, nor are there any treatments that help most sufferers.
  • Using Metabolomics to Investigate Biological Pathways and Networks (R01)external link icon
    Release Date: June 30, 2006
    Application Receipt Date: October 20, 2006
    The goal of the current funding opportunity is to apply metabolomics technology to the study of pathway and network regulation in normal and disease states that are not easily approached by other technologies. Ideally, applications will study more complete views of pathways and networks defined by changes in metabolite concentrations including their sources, destinations, and activating or inhibiting feedback effects on pathway or network regulation.
  • Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32)external link icon
    Release Date: June 16, 2006
    Other Important Dates: See announcement for details
    The National Institutes of Health (NIH) will award these grants to eligible institutions as the primary means of supporting graduate and postdoctoral research training to help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the Nation's biomedical, behavioral and clinical research agenda. The primary objective is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation.
  • Diet, Epigenetic Events, and Cancer Prevention (R01)external link icon
    Release Date: May 16, 2006
    Other Important Dates: See announcement for details
    The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. See also R21 and R03.
  • Diet, Epigenetic Events, and Cancer Prevention (R21)external link icon
    Release Date: May 16, 2006
    Other Important Dates: See announcement for details
    The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. See also R01 and R03.
  • Diet, Epigenetic Events, and Cancer Prevention (R03)external link icon
    Release Date: May 16, 2006
    Other Important Dates: See announcement for details
    The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. See also R01 and R21.
  • Mechanisms of Alcohol-Associated Cancers (R21) PA-06-270external link icon
    Release Date: March 24, 2006
    Other Important Dates: See announcement for details
    The purpose of this PA (PA-06-270) is to encourage research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms by which chronic alcohol consumption leads to the development of cancers of various organs such as oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast. This includes investigating roles of various factors such as acetaldehyde, CYP2E1, VEGF, impaired immune function, and impaired metabolism of SAMe, folate, iron, and vitamin A by alcohol. (See also the R01 listing.)
  • Mechanisms of Alcohol-Associated Cancers (R01) PA-06-269external link icon
    Release Date: March 24, 2006
    Other Important Dates: See announcement for details
  • Exploratory/Developmental Clinical Research Grants In Obesity (R21)external link icon
    Release Date: March 17, 2006
    Other Important Dates: See announcement for details
    The goal of this initiative is to encourage exploratory/developmental clinical studies that will accelerate the development of effective interventions for prevention or treatment of overweight or obesity in either adults or children. Exploratory epidemiological research with a goal of informing translational/clinical research will also be supported within this program. This FOA will use the NIH Exploratory/Developmental Research Grant (R21).
  • Improving Diet and Physical Activity Assessment (R01)external link icon
    Release Date: December 23, 2005
    Other Important Dates: See announcement for details
    The measurement of usual dietary intake or physical activity over varying time periods or in the past, by necessity, has relied on self-report instruments. Such subjective reporting instruments are cognitively difficult for respondents, and are prone to considerable measurement errors that may vary among population subgroups and depend on the time frame considered and the characteristics of the respondents. Institutes and Offices at the NIH, including ODS, are interested in promoting innovative research to enhance the quality of measurements of dietary intake and physical activity. Applications may include development of: novel assessment approaches; better methods to evaluate instruments; assessment tools for culturally diverse populations; across various age-groups including older adults; improved technology or applications of existing technology; or statistical methods to assess or correct for measurement errors or biases.
  • Training for a New Interdisciplinary Research Workforceexternal link icon
    Release Date: December 16, 2005
    Application Receipt Date: April 7, 2006
    This RFA is an initiative of the NIH Roadmap (http://nihroadmap.nih.gov/), a series of activities whose goal, in keeping with the NIH mission of uncovering new knowledge about the prevention, detection, diagnosis, and treatment of disease and disability, is to accelerate both the pace of discovery in these key areas and the translation of therapies from bench to bedside.
  • Mentored Quantitative Research Development Award (K25)external link icon
    Release Date: December 2, 2005
    Other Important Dates: See announcement for details
    The K25 Award will support the career development of such investigators who make a commitment to basic or clinical biomedicine, bioengineering, bioimaging or behavioral research. This award provides support for a period of supervised study and research for productive professionals with quantitative backgrounds who have the potential to integrate their expertise with NIH-relevant research and develop into productive investigators. It is intended for research-oriented investigators from the postdoctoral level to the level of senior faculty.
  • Dissemination and Implementation Research in Healthexternal link icon
    Release Date: October 25, 2005
    Other Important Dates: See announcement for details
    The purpose of this dissemination and implementation research program announcement is to support innovative approaches to understanding and overcoming the barriers to the adoption of health promotion, disease prevention, diagnostic and treatment interventions that previous intervention research has shown to be effective, but where adoption to date has been limited or significantly delayed.
  • NIDDK Career Transition Award (K22) in Patient-Oriented Researchexternal link icon
    Release Date: October 15, 2005
    Other Important Dates: See announcement for details
    The NIDDK Career Transition Award, which uses the K22 mechanism, is a five-year mentored career development award whose goal is to attract outstanding physician-scientists to a clinical research training program that will endow them with the fundamental skills and investigational tools necessary for successful careers in patient-oriented research, and to facilitate their successful transition to an extramural environment as independent researchers.
  • Mentored Research Scientist Development Award (K01)external link icon
    Release Date: October 4, 2005
    Other Important Dates: See announcement for details
    The purpose of the Mentored Research Scientist Development Award (K01) is to provide support and “protected time” (three, four, or five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Awards are not renewable, nor are they transferable from one principal investigator to another.

Fiscal Year 2005

  • Global Research Training in Population Healthexternal link icon
    Release Date: August 26, 2005
    Application Receipt Date: January 13, 2006
    The Fogarty International Center (FIC), in collaboration with the National Institute of Child Health and Human Development (NICHD) and the Office of Dietary Supplements (ODS) of the National Institutes of Health, invites applications from non-profit public or private institutions in the U.S. and low- and middle-income countries to support advanced international research training in population health sciences.
  • Paul B. Beeson Career Development Awards in Agingexternal link icon
    Release Date: August 25, 2005
    Application Receipt Date: November 23, 2005
    This program provides three to five years of mentored career development support to clinically-trained faculty members in strong research environments to enable them to gain skills and experience in aging research, under the guidance of a mentor or mentors, and to establish an independent program of research in this field. It also includes an annual meeting that allows opportunities to partner with national mentors and fellow awardees.
  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD Fellowsexternal link icon
    Release Date: August 8, 2005
    Other Important Dates: See announcement for details
    The participating Institutes award this Kirschstein-NRSA individual fellowship (F30) to promising applicants with the potential to become productive, independent, highly trained physician-scientists, including patient-oriented physician-scientists in their scientific mission areas. This funding opportunity supports individual predoctoral F30 fellowships with the expectation that these training opportunities will increase the number of future investigators in basic, translational and clinical research who are physician scientists.
  • Mentored Patient-Oriented Research Career Development Awardexternal link icon
    Release Date: July 22, 2005
    Other Important Dates: See announcement for details
    The purpose of this award is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. This mechanism provides support for three to five years of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators focusing on patient-oriented research.
  • Basic and Preclinical Research on Complementary and Alternative Medicine (CAM)external link icon
    Release Date: July 15, 2005
    Other Important Dates: See announcement for details
    The National Center for Complementary and Alternative Medicine (NCCAM) invites applications for funding of basic, mechanistic, and/or preclinical research in all domains of CAM, in order to elucidate the underlying mechanisms of action of CAM therapies and to provide a stronger foundation for ongoing and planned clinical studies. NCCAM encourages outstanding CAM and conventional researchers to focus on opportunities in CAM research and to employ cutting-edge technologies to strengthen the knowledge bases needed to improve clinical practice. The National Cancer Institute (NCI) and the Office of Dietary Supplements (ODS) share programmatic interests in some areas of CAM research with NCCAM.
  • AIDS International Training and Research Program external link icon
    Release Date: July 14, 2005
    Other Important Dates: See announcement for details
    The purpose of this announcement is to invite applications from eligible institutions for innovative, collaborative training programs that would contribute to the long-term goal of building sustainable research capacity in HIV/AIDS and HIV-related conditions at institutions in low- and middle-income countries. These research-training programs will strengthen scientific knowledge and skills to enhance prevention of and treatment and care for HIV/AIDS and HIV-related conditions in these countries.
  • Complementary and Alternative Medicine Career Transition Award (K22)external link icon
    Release Date: June 23, 2005
    Other Important Dates: See announcement for details
    The goal of this funding opportunity is to provide support for outstanding advanced postdoctoral research scientists during their transition to independence. The award will provide support for up to 1 year of postdoctoral research training, and 3 years of research support as an independent investigator. This award is limited to postdoctoral trainees who propose research in complementary and alternative medicine (CAM) for the independent investigator phase of this award.
  • Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis)external link icon
    Release Date: June 10, 2005
    Other Important Dates: See announcement for details
    The National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms of alcoholic and nonalcoholic fatty liver. This announcement addresses several areas considered to be high priority for liver disease research as delineated in the recently published Trans-NIH Action Plan for Liver Disease Research (http://liverplan.niddk.nih.gov), specifically in the area of fatty liver disease.
  • Ruth L. Kirschstein National Research Service Award Short-Term Institutional Research Training Grants (T35)external link icon
    Release Date: June 3, 2005
    Other Important Dates: See announcement for details
    The objectives of the short-term research training (T35) program are to develop or enhance research training opportunities for individuals interested in careers in biomedical, behavioral and clinical research. The program may also be used to support other types of predoctoral and postdoctoral training in focused, often emerging, scientific areas relevant to the mission of the NIH funding Institute or Center. The training program must be in either the basic, clinical, or behavioral research aspects of the health-related sciences, and should be of sufficient depth to enable selected trainees, upon completion of the program, to have a thorough exposure to the principles underlying the conduct of research.
  • Brain Disorders in the Developing World: Research Across the Lifespanexternal link icon
    Release Date: May 3, 2005
    Other Important Dates: See announcement for details
    The purpose of the Brain Disorders in the Developing World: Research Across the Lifespan program announcement is to support the development and conduct of innovative, collaborative research and research training projects, between developed and developing country scientists, on brain disorders throughout life, relevant to low- and middle-income nations. The collaborative research programs are expected to 1) involve research on neurological/ neurodevelopmental (including sensory, motor, cognitive and behavioral) function and impairment throughout life and 2) contribute to the long-term goal of building sustainable research capacity in developing countries to initiate and conduct such research.
  • Development of Disease Biomarkersexternal link icon
    Release Date: April 27, 2005
    Other Important Dates: See announcement for details
    This Program Announcement will provide resources to validate candidate biomarkers for well-defined human diseases of liver, kidney, urological tract, digestive and hematologic systems, and endocrine and metabolic disorders, diabetes and its complications, and obesity, for which there are no or very few biomarkers, or for which standard biomarkers are currently prohibitively invasive or expensive.
  • Nutrition and Diet in the Causation, Prevention, and Management of Heart Failureexternal link icon
    Release Date: April 15, 2005
    Other Important Dates: See announcement for details
    The purpose of this Program Announcement is to encourage submission of investigator-initiated research applications on the role of nutrition and diet in the causation, prevention, and treatment of cardiomyopathies and heart failure. Basic, translational, and applied interdisciplinary research applications with rigorous hypothesis-testing designs for projects in animals or humans are of interest. The overall goal is to develop a satisfactory science base for preventive approaches in high-risk individuals and for rational nutritional management of patients in various stages of heart failure.
  • Global Research Initiative Program, Social Scienceexternal link icon
    Release Date: March 31, 2005
    Other Important Dates: See announcement for details
    The goal of this initiative is to provide funding opportunities for the increasing pool of foreign biomedical and behavioral scientists, clinical investigators, nurses, and other health professionals with state-of-the-art knowledge of research methods to advance critical issues in global health upon their return to their home countries through behavioral and social sciences research.
  • NIDDK Mentored Research Scientist Development Award (K01)external link icon
    Release Date: March 8, 2005
    Other Important Dates: See announcement for details
    The purpose of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Mentored Research Scientist Development Award (K01) is to provide "protected time" for junior research scientists to facilitate their transition from the mentored to the independent stages of their careers in biomedical research. The NIDDK invites K01 applications from advanced postdoctoral and/or newly independent research scientists (usually with a Ph.D. degree) in biomedical or behavioral sciences who are pursuing careers in research areas supported by the NIDDK.
  • In Utero Exposure to Bioactive Food Components and Mammary Cancer Riskexternal link icon
    Release Date: March 1, 2005
    Other Important Dates: See announcement for details
    This funding opportunity encourages applications that apply new high-throughput genomic, epigenomic, proteomic, and metabolomic technologies to determine how dietary exposures in utero influence adult breast cancer susceptibility. The resulting information will help define effective maternal dietary intervention strategies for breast cancer prevention in her offspring.
  • Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciencesexternal link icon
    Release Date: February 18, 2005
    Other Important Dates: See announcement for details
    The aim of the program is to encourage and support broad, early-stage (pre-dissertation) training in the neurosciences by offering institutions a single comprehensive training grant. Support through this program focuses on the early years of graduate training, typically the first and second years, before full-time thesis research begins.
  • Probiotics for Pediatric Illnessesexternal link icon
    Release Date: December 28, 2004
    Other Important Dates: See announcement for details
    The purpose of this PA is to provide support for pilot research on mechanism(s) of action, safety and efficacy of probiotics, as well as for more robust intervention studies for the prevention and treatment of pediatric illnesses for which more convincing preliminary data are available.
  • Chronic Fatigue Syndrome: Pathophysiology and Treatmentexternal link icon
    Release Date: December 21, 2004
    Other Important Dates: See announcement for details
    The Office of Research on Women's Health (ORWH) and cosponsoring Institutes and Offices (IC) of the National Institutes of Health (NIH) invite submission of investigator-initiated research grant applications to support research on the epidemiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS) in diverse groups and across the life span.
  • Assay Development for High Throughput Molecular Screeningexternal link icon
    Release Date: December 7, 2004
    Application Receipt Date: February 14, 2005
    The purpose of this RFA is to facilitate the discovery of new molecular probes for investigating biological function by funding the development and adaptation of biological assays for automated high throughput molecular screening (HTS). This is one component of the NIH Molecular Libraries and Imaging Roadmap Initiative.
  • Building Interdisciplinary Research Careers in Women's Healthexternal link icon
    Release Date: November 24, 2004
    Application Receipt Date: February 23, 2005
    The goal of this initiative is to promote the performance of interdisciplinary research and transfer of findings that will benefit the health of women, including sex/gender similarities or differences in biology, health or disease. The programs will accomplish these goals by bridging advanced training with research independence, as well as bridging scientific disciplines or areas of interest. This will increase the number and skills of investigators at awardee institutions through a mentored research and career development experience leading to an independent interdisciplinary scientific career addressing women's health.
  • Preventing Mitochondrial Oxidative Stress in Diabetes and Obesityexternal link icon
    Release Date: November 23, 2004
    Application Receipt Date: February 24, 2005
    Hyperglycemia is a significant causative factor for the complications of diabetes mellitus, which results in significant morbidity and mortality for millions of Americans. Recent advances on the cellular effects of hyperglycemia places the overproduction of reactive oxygen species (ROS) by the mitochondrial electron transport chain as a strong candidate for the core abnormality that leads to other biochemical and cellular defects and the resulting tissue injury. The purpose of this RFA is to encourage the translation of these recent advances into therapies that can interrupt the increase in mitochondrial ROS and prevent their role in diabetic complications.
  • Interdisciplinary Training: Behavior, Environment and Biologyexternal link icon
    Release Date: November 19, 2004
    Application Receipt Date: February 11, 2005
    This postdoctoral, institutional National Research Service Award (NRSA) will support the establishment of innovative programs that provide formal coursework and research training in a new interdisciplinary field to individuals holding advanced degrees in a different discipline. These training programs are required to include a behavioral or social science discipline. The NIH is especially interested in training programs that integrate the behavioral and/or social sciences with the more traditional biomedical sciences.
  • Pilot-Scale Libraries for High-Throughput Screeningexternal link icon
    Release Date: November 18, 2004
    Application Receipt Date: February 15, 2005
    The Institutes and Centers (ICs) of the NIH invite applications for funding from the NIH Molecular Libraries Roadmap program for the generation of pilot-scale chemical diversity libraries. These libraries will be used for high-throughput biological screening by the Molecular Libraries Screening Center Network (MLSCN).
  • New Methodologies for Natural Products Chemistryexternal link icon
    Release Date: November 17, 2004
    Application Receipt Date: January 24, 2005
    The Institutes and Centers (ICs) of the NIH invite applications for funding from the NIH Molecular Libraries Roadmap program for the development of novel methodologies related to natural products chemistry. The goal of this RFA is to stimulate the development of a new generation of methods for natural products chemistry, and in doing so, to reinvigorate the investigation of nature as a prolific source of small-molecules with the potential to interact with all of the proteins that participate in cellular processes in health and disease.
  • International Cooperative Biodiversity Groups (ICBG)external link icon
    Release Date: October 26, 2004
    Application Receipt Date: February 16, 2005
    The Participating Agencies invite applications for the establishment of "International Cooperative Biodiversity Groups" (ICBG) to address the interdependent issues of biodiversity conservation, economic capacity, and human health through discovery and development of therapeutic agents for diseases of importance in developing countries, as well as those important to developed countries.
  • Metals in Medicineexternal link icon
    Release Date: October 6, 2004
    Other Important Dates: See announcement for details
    The objective of this program announcement (PA) is to encourage research that bridges the areas of inorganic chemistry and medicine. It continues the program previously announced as PA01-071. The mechanisms by which organisms control transition metal ions and the roles of these metals in cellular regulation and signaling in health and disease are of principal interest.

Fiscal Year 2004

  • Exfoliated Cells, Bioactive Food Components, and Cancer external link icon
    Release Date: July 9, 2004
    Other Important Dates: See announcement for details
    The objective of this PA is to encourage interdisciplinary collaborations between scientists engaged in research using exfoliated cells and those conducting nutrition research related to cancer prevention. This research will help determine the utility of exfoliated cells as a model system to monitor both the absorption and retention of bioactive food components and the concomitant alterations in genomic and epigenetic events that occur in intact cells.
  • Supplements to Promote Reentry in to Biomedical and Behavioral Research Careers external link icon
    Release Date: July 9, 2004
    Other Important Dates: See announcement for details
    The participating Institutes and Centers of the National Institutes of Health (NIH) along with the Office of Research on Women’s Health announces a continuing program for administrative supplements to research grants to support individuals with high potential to reenter an active research career after taking time off to care for children or attend to other family responsibilities. The aim of these supplements is to encourage such individuals to reenter research careers within the missions of all the program areas of NIH.
  • Understanding Mechanisms of Health Risk Behavior Change in Children and Adolescents external link icon
    Release Date: July 6, 2004
    Other Important Dates: See announcement for details
    The goal of this Program Announcement is to promote optimal physical and mental health in children and adolescents. This may be accomplished by research to enhance our understanding of the origin, evolution, and termination of health risk behaviors and, ultimately, by the development of effective prevention and intervention strategies designed to maintain healthy behaviors and prevent health risk behaviors.
  • Innovative and Exploratory Research In Digestive Diseases and Nutrition external link icon
    Release Date: June 14, 2004
    Other Important Dates: See announcement for details
    The aim of this program announcement is to stimulate the application of highly novel approaches to important areas of digestive diseases (including associated cancers) and nutrition research. This mechanism is primarily aimed at attracting and supporting new investigators in these research fields.
  • Short Course: Integrative and Organ Systems Pharmacology external link icon
    Release Date: May 3, 2004
    Application Receipt Date: June 25, 2004
    This RFA solicits proposals for Education Projects that will introduce students to the knowledge and skills needed for studies of integrative organ system and whole organism biological responses to drugs and other physiological perturbations.
  • Long-Term Weight Maintenance: Basic and Clinical Studiesexternal link icon
    Release Date: April 19, 2004
    Other Important Dates: See announcement for details
    The goal of this program announcement is to invite research applications investigating basic and clinical aspects of long-term weight maintenance. Applications investigating mechanisms underlying weight stability and/or weight regain after intentional weight loss, as well as clinical studies investigating the role of behavioral, nutritional, exercise, or other interventions in enhancing long-term weight maintenance will be supported.
  • Psychopharmacology of Widely Available Psychoactive Natural Productsexternal link icon
    Release Date: April 5, 2004
    Other Important Dates: See announcement for details
    Under this PA, National Institute on Drug Abuse, Office of Dietary Supplements, and the National Institute of Mental Health, invite research grant applications that characterize the chemistry, psychopharmacology, and/or toxicology of acute and chronic exposure to psychoactive natural products, as well as the transition in the use of these products to licit or illicit drugs of abuse. For the purposes of this PA, psychoactive natural products are defined as fungus- or plant-derived products that are taken primarily for their effects on the central nervous system (e.g., stimulant, depressant, and/or hallucinogenic effects), rather than for treatment, medicinal or therapeutic effects.
  • Small Grant Program for NIDDK K08/K23 Recipientsexternal link icon
    Release Date: March 8, 2004
    Other Important Dates: See announcement for details
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Dietary Supplements (ODS) re-announce a program that provides NIDDK-supported K08 and K23 recipients the opportunity to apply for Small Grant (R03) support to run concurrently with the latter years of their K08/K23 award. Through the use of this mechanism, which allows up to $50,000 per year for two years in additional research development costs, the NIDDK is seeking to enhance the capability of its K08 and K23 award recipients to conduct research as they complete their transition to fully independent investigator status.
  • Transition to Independent Positions (TIP)external link icon
    Release Date: March 8, 2004
    Application Receipt Date: July 13, 2004
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Dietary Supplements (ODS) re-announce a program that provides NIDDK-supported K08 and K23 recipients the opportunity to apply for Small Grant (R03) support to run concurrently with the latter years of their K08/K23 award. Through the use of this mechanism, which allows up to $50,000 per year for two years in additional research development costs, the NIDDK is seeking to enhance the capability of its K08 and K23 award recipients to conduct research as they complete their transition to fully independent investigator status.
  • International Research Scientist Development Awardexternal link icon
    Release Date: February 10, 2004
    Other Important Dates: See announcement for details
    The Fogarty International Center (FIC), the National Institute of Nursing Research (NINR), the NIH Office of Dietary Supplements (ODS), and the National Institute of Environmental Health Sciences (NIEHS) solicit proposals for the International Research Scientist Development Award (IRSDA). This program supports U.S. postdoctoral biomedical, social, and behavioral scientists in the formative stages of their careers to conduct research in, or extend their research into, developing countries.
  • Meetings and Networks for Methodological Development in Interdisciplinary Researchexternal link icon
    Release Date: January 23, 2004
    Application Receipt Date: April 26, 2004
    The purpose of this RFA is to stimulate the development of methods and measures in the behavioral or social sciences in order to more fully integrate the scientific approaches and advances in these disciplines into interdisciplinary research designed to solve complex health problems. NIH is especially interested in applications that identify a topic in human health/well-being research that can be significantly advanced by using an interdisciplinary approach bringing together a new combination of disciplines and by developing innovative, interdisciplinary approaches and methods.
  • High Throughput Molecular Screening Assay Developmentexternal link icon
    Release Date: January 20, 2004
    Application Receipt Date: March 26, 2004
    The purpose of this RFA is to encourage the use of high throughput molecular screening (HTS) by funding the development and adaptation of biological assays for automated screening. This is one component of the NIH Molecular Libraries and Imaging Roadmap Initiative (http://nihroadmap.nih.gov/molecularlibraries/index.asp). Other components of the Initiative will support automated molecular screening at the Molecular Libraries Screening Centers, the creation of a chemical compound library at the Molecular Libraries Small Molecule Repository, and the development of related technologies. The Office of Dietary Supplements has signed onto this initiative.
  • Dietary Supplement Research Centers: Botanicalsexternal link icon
    Release Date: December 22, 2003
    Application Receipt Date: December 22, 2003
    The ODS, NCCAM, and NIEHS invite applications to support research centers of excellence which will (1) promote interdisciplinary collaborative study of botanicals, particularly those that are found as ingredients in dietary supplements and (2) conduct research of high potential for being translated into practical benefits for human health.
  • Training for a New Interdisciplinary Research Workforce external link icon
    Release Date: December 22, 2003
    Application Receipt Date: March 10, 2004
    The purpose of this RFA is to encourage and enable the development of an interdisciplinary workforce by ensuring that undergraduate, pre-doctoral, and postdoctoral students receive the didactic and research experiences necessary to lead and/or engage in integrative and team approaches to solve complex biomedical and health problems. To accomplish this aim, the National Institutes of Health invites applications for developing and implementing novel training programs focused on new interdisciplinary science.
  • Diet Composition and Energy Balanceexternal link icon
    Release Date: December 10, 2003
    Other Important Dates: See announcement for details
    The goal of this program announcement is to invite research applications investigating the role of diet composition in energy balance, including studies in both animals and humans. Both short and longer-term studies would be encouraged, ranging from basic studies investigating the impact of micro-or macronutrient composition on appetite, metabolism, and energy expenditure through clinical studies evaluating the efficacy of diets differing in micro- or macronutrient composition, absorption, dietary variety, or energy density for weight loss or weight maintenance.
  • Supplements for Methodological Innovations in the Behavioral and Social Sciencesexternal link icon
    Release Date: December 8, 2003
    Application Receipt Date: February 13, 2004
    The Institutes, Centers and Offices of the National Institutes of Health (NIH) invite NIH-funded investigators to submit supplemental research grant applications to develop methodological innovations in the behavioral and social sciences. These modest supplements will support the addition of a methodological development component to already-funded NIH research projects.
  • Curriculum Development Award in Interdisciplinary Research external link icon
    Release Date: November 24, 2003
    Application Receipt Date: February 24, 2004
    The Curriculum Development Award in Interdisciplinary Research supports the development of innovative courses, curricula and educational approaches designed to train interdisciplinary scientists in emerging sciences.
  • NIH Clinical Trials Planning Grant (R34) Programexternal link icon
    Release Date: October 16, 2003
    Other Important Dates: See announcement for details
    The purpose of the NIH Clinical Trial Planning Grant (R34) is to provide support for the development of a Phase III clinical trial, including the establishment of the research team, the development of tools for data management and oversight of the research, the definition of recruitment strategies, and the finalization of the protocol and other essential elements of the study included in a manual of operations/procedures.

Fiscal Year 2003

  • Updated Guidelines for Conferences and Scientific Meetingsexternal link icon
    Release Date: September 24, 2003
    Other Important Dates: See announcement for details
    This Program Announcement provides updated guidelines for National Institutes of Health (NIH) support of scientific meetings. It replaces the previous guidelines issued in the NIH GUIDE on October 30, 1998.
  • Bench to Bedside Research on Type 1 Diabetes and Its Complicationsexternal link icon
    Release Date: August 14, 2003
    Application Receipt Date: February 20, 2004
    The purpose of this request for applications is to establish partnerships between clinical and basic biomedical researchers with the goal of translating advances in our understanding of the molecular basis of type 1 diabetes and its complications into new therapies for the prevention, treatment and cure of this disease.
  • Innovative Partnerships in Type 1 Diabetesexternal link icon
    Release Date: June 26, 2003
    Application Receipt Date: November 13, 2003
    The purpose of this request for applications (RFA) is to attract new research talent to type 1 diabetes research, strengthen the ongoing efforts of type 1 diabetes researchers by providing access to specialized expertise or technologies relevant to their research, and facilitate the formation of interdisciplinary research partnerships to investigate significant biological and medical problems associated with type 1 diabetes.
  • Global Health Research Initiative Program for new Foreign Investigators (GRIP)external link icon
    Release Date: May 16, 2003
    Other Important Dates: See announcement for details
    This Program Announcement (PA) is intended to promote productive re-entry of NIH-trained foreigninvestigators from low-income countries into their home countries as part of a broader program to enhance the scientific research infrastructure in developing countries, to stimulate research on a wide variety of high priority health-related issues in these countries, and to advance NIH efforts to address health issues of global import.
  • The Fetal Basis of Adult Disease: Role of the Environmentexternal link icon
    Release Date: May 12, 2003
    Other Important Dates: See announcement for details
    The purpose of this program announcement with a set aside of funds and a Special Emphasis Panel review by the NIH Center for Scientific Review is to stimulate research in an important and emerging area of developmental toxicology: the effects of in utero exposures that cause permanent functional changes that are not overtly, grossly teratogenic yet that result in increased susceptibility to disease/dysfunction later in the life span. This program announcement seeks to encourage the application of the new high-throughput functional-genomic, metabonomic, proteomic, and bioinformatic technologies to pursue an understanding of these latent effects of in utero environmental insult.
  • Cranberry: Urinary Tract Infection and Other Conditionsexternal link icon
    Release Date: February 21, 2003
    Application Receipt Date: May 20, 2003
    The purpose of this initiative is to support basic and clinical research on the role of cranberry (Vaccinium macrocarpon) in the prevention and treatment of urinary tract infections (UTI), other infections, and other conditions for which there is credible evidence of efficacy. For clinical trials, preference will be given to those that also test mechanistic hypotheses. This research may lead to definitive Phase III trials to determine the efficacy of cranberry in the prevention and/or treatment of UTI or other conditions. Products of primary interest are (1) cranberry juice cocktail and (2) encapsulated powders, and their matching placebos.
  • Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32) external link icon
    Release Date: February 6, 2003
    Other Important Dates: See announcement for details
    The goal of this program announcement is to award individual postdoctoral fellowships (F32) to promising applicants with the potential to become productive, independent investigators in fields related to the mission of the NIH constituent institutes and centers.
  • Brain Disorders in the Developing World: Research Across the Lifespan external link icon
    Release Date: November 7, 2002
    Application Receipt Date: March 11, 2003
    This request for applications (RFA) solicits applications to plan and develop collaborative research and capacity building projects on brain disorders throughout life relevant to low- and middle-income nations. Applicants are expected to develop innovative, collaborative research programs that would contribute to the long-term goal of building sustainable research capacity in neurological/neurodevelopmental (including sensory, motor, cognitive and behavioral) impairment throughout life.

Fiscal Year 2002

  • Diet, DNA Methylation and Other Epigenetic Events, and Cancer Preventionexternal link icon
    Release Date: September 27, 2002
    Application Receipt Date: March 18, 2003
    This request for applications (RFA) invites applications for new R01 and R21 grants which are focused on research leading to the elucidation of mechanism(s) by which dietary factors influence epigenetic processes as well as increasing the understanding of these processes in cancer prevention.
  • Diet, DNA Methylation and Other Epigenetic Events, and Cancer Prevention: Competing Supplementsexternal link icon
    Release Date: September 27, 2002
    Other Important Dates: See announcement for details
    This program announcement (PA) invites competitive supplement grant applications for existing NCI grants to undertake adjunct research projects leading to elucidation of mechanism(s) by which dietary factors influence epigenetic processes as well as increasing the understanding of these processes in cancer prevention.
  • S-Adenosyl-L-Methionine (SAMe) and Liver Diseaseexternal link icon
    Release Date: January 30, 2002
    Application Receipt Date: May 15, 2002
    This request for applications (RFA) invites applications for grants proposing innovative basic and preclinical research to understand how SAMe may be effective in the treatment of liver disease caused by alcohol and other factors such as hepatitis C virus (HCV).
  • Global Health Research Initiative Program for New Foreign Investigators (R01) external link icon
    Release Date: January 29, 2002
    Application Receipt Date: April 19, 2002
    This request for applications (RFA) is intended to promote productive re-entry of NIH-trained foreign investigators into their home countries as part of a broader program to enhance the scientific research infrastructure in developing countries, to stimulate research on a wide variety of high priority health-related issues in these countries, and to advance NIH efforts to address health issues of global import.
  • Alternative Therapies for Benign Prostate Symptoms - Clinical Trials Consortiumexternal link icon
    Release Date: January 16, 2002
    Application Receipt Date: April 15, 2002
    This request for applications (RFA) invites cooperative agreement grant applications to establish a research consortium to conduct a randomized controlled clinical trial of Serenoa repens (Saw palmetto) and Pygeum africanum in men with benign prostatic hyperplasia (BPH).
  • Pathophysiology and Treatment of Chronic Fatigue Syndrome (CFS) external link icon
    Release Date: December 11, 2001
    Other Important Dates: See announcement for details
    This program announcement invites submission of investigator-initiated research grant applications to support research on the pathophysiology and treatment of chronic fatigue syndrome (CFS) in diverse groups and across the life span.

Fiscal Year 2001

  • Mechanisms in Nutrition and Infection (August 29, 2001) external link icon
    Release Date: August 29, 2001
    Other Important Dates: See announcement for details
    This program announcement solicits basic, epidemiological and clinical research on nutrition (including dietary supplements) and infection.
  • Chromium as Adjuvant Therapy for Type 2 Diabetes and Impaired Glucose Toleranceexternal link icon
    Release Date: July 2, 2001
    Other Important Dates: See announcement for details
    The purpose of this program announcement is to encourage 1) basic studies of chromium action on insulin secretory and signaling pathways and 2) clinical studies to assess the safety and efficacy of chromium as an adjuvant treatment of type 2 diabetes and/or impaired glucose tolerance.
  • The Role of Antioxidants in the Prevention of Diabetic Complicationsexternal link icon
    Release Date: June 27, 2001
    Other Important Dates: See announcement for details
    This program announcement solicits basic and clinical research applications to study the use of vitamin E and other antioxidants in the prevention or amelioration of diabetic complications.
  • Metals in Medicineexternal link icon
    Release Date: March 19, 2001
    Other Important Dates: See announcement for details
    The objective of this program announcement is to encourage research that bridges the areas of inorganic chemistry and medicine. The mechanisms by which organisms control transition metal ions and the roles of these metals in cell-cell signaling are of primary interest. The interactions of synthetic inorganic complexes with living systems and their components are a second area of interest.

Fiscal Year 2000

Fiscal Year 1999

  • ODS-Initiated Request for Applications (March 5, 1999)
    Release Date: March 5, 1999
    Application Receipt Date: March 5, 1999
    In response to a Congressional mandate, the ODS initiated its first grant and invited proposals to establish a Center for Dietary Supplements Research with a focus on botanicals.
    As a result of this Request for Applications, two grant awards were made in 1999, establishing the first NIH-funded Dietary Supplement Research Centers