Antioxidants: Strategies For Interventions in Aging and Age-Related Diseases

National Institute on Aging
&
Office of Dietary Supplements
National Institutes of Health

July 14-16, 1999
Chevy Chase, Maryland

AGENDA

JULY 14, 1999

OPENING LECTURE
INTRODUCED BY PAMELA E. STARKE-REED
Director, Office of Nutrition, National Institute on Aging, National Institutes of Health, Bethesda, Maryland

06:00 - 07:00 pm Oxidative cytotoxicity in aging and neurodegeneration
Robert H. Brown 
Massachusetts General Hospital-East, Charlestown, Massachusetts
 

JULY 15, 1999

SESSION I:  ANTIOXIDANTS, CELLULAR FUNCTIONS, AND AGING
CHAIRPERSON Raj Sohal
Department of Biological Sciences, Southern Methodist University, Dallas, Texas

09:00 - 09:40   Mitochondria; a link between reactive nitrogen species and aging
Victor Darley-Usmar
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

09:40 - 10:20   Regulation of leukocyte-endothelial cell interactions by nitric oxide
Mathew Grisham
Department of Physiology and Biophysics, LSU Medical Center, Shreverport, Louisiana

10:20 - 11:00   The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite
Steven P. A. Goss
Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin

11:00 - 11:10 Coffee Break

11:10 - 11:50   Mechanisms of vitamin E regulation
Maret G. Traber
Linus Pauling Institute, Department of Nutrition and Food Management, Oregon State University, Corvallis, Oregon

11:50 - 12:20 Mitochondria dysfunction in Friedreich's ataxia and Coenzyme Q analogs
Gino A. Cortopassi
Department of Molecular Bioscience, 1311 Haring Hall, University of California, Davis, California

12:20 - 01:00   Effects of coenzyme Q and alpha-tocopherol on the mitochondrial generation of oxidants
Raj Sohal
Department of Biological Sciences, Southern Methodist University, Dallas, Texas

01:00 Lunch
 

SESSION II:  ANTIOXIDANTS, APOPTOSIS, AND AGING
CHAIRPERSON Enrique Cadenas
Department of Molecular Pharmacology, School of Pharmacy, University of Southern California, Los Angeles, California

02:00 - 02:40 Signal transduction in neuronal death
J. Regino Perez-Polo
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas

02:40 - 03:20 Redox regulation of the JAK/STAT pathway
Brent H. Cochran
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

03:20 - 04:00 Regulation of signal transduction and gene expression by alpha-tocopherol
Angelo Azzi
Institut Für Biochemie and Molekular Biologie, Universität Bern, Switzerland

04:00 - 04:40 Oxidative stress and apoptotic cell death
Rajiv R. Ratan
Department of Neurology, Harvard Institute of Medicine, Boston, Massachusetts

04:40 - 05:20 Some essential roles of specific selenoproteins and effects of toxic levels of selenium
Thressa C. Stadtman
Laboratory of Biochemistry, National Health, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

05:20 - 06:00 Cellular steady-state levels of hydrogen peroxide that determine apoptosis and necrosis
Enrique Cadenas
Department of Molecular Pharmacology, School of Pharmacy, University of Southern California, Los Angeles, California
 

JULY 16, 1999

SESSION III:  ANTIOXIDANTS IN SIGNAL TRANSDUCTION PATHWAYS AND GENE EXPRESSION
CHAIRPERSON Gino A. Cortopassi
Department of Molecular Biosciences, 1311 Haring Hall, University of California, Davis, California

09:00 - 09:40 Induction of apoptosis by dopamine through an oxidation-mediated AP-1and NF-kB activation pathway
Yongquan Luo
Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, 
Baltimore, Maryland

09:40 - 10:20 Monoamine oxidase gene and behavior:  modulation by natural antioxidants
Jean C. Shih
Department of Molecular  Pharmacology and Toxicology, University of Southern California, Los Angeles, California

10:20 - 11:00 Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer's disease
Mark A. Smith
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio

11:00 - 11:10 Coffee Break

11:10 - 11:50 Intracellular events in glutamate-induced death of HT4 neuronal cells: role of signal transduction pathways, antioxidants, and reactive oxygen species
Chandan K. Sen
Environmental Energy Technologies, Lawrence Berkeley Laboratory, University of California, Berkeley, California

11:50 - 12:30 Strategies for modulating cell signalling pathways linked to the development of apoptosis and proliferation by oxidant stresses in lung
Brooke T. Mossman
Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont

12:30 Lunch

02:00 Round Table Discussion
Search for antioxidant intervention strategies in aging and neurodegeneration

Discussion Leaders

Pamela E. Starke-Reed
Office of Nutrition, National Institute on Aging, National Institutes of Health, Bethesda, Maryland

Raj Sohal
Department of Biological Sciences, Southern Methodist University, Dallas, Texas