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Mechanistic Studies of Cardiovascular Effects of Botanicals


Mechanistic Studies of Cardiovascular Effects of Botanicals

Sponsored by: National Heart, Lung and Blood Institute
Office of Dietary Supplements
National Center for Complementary and Alternative Medicine

August 22-23, 2002
Bethesda, MD


Conference Goals:

  • Assess the current state of research on the mechanisms of action responsible for the cardiovascular effect of several widely-used herbal dietary supplements, including garlic, ginkgo, hawthorn and phytoestrogens and the evidence for their clinical efficacy.
  • Develop recommendations to identify research opportunities and to discuss potential clinical use of botanicals.
  • Promote exchange of information and ideas, identify opportunities and foster collaboration among scientists who are interested in using botanicals in cardiovascular research.

Agenda:

Thursday, August 22, 2002

8:00 - 8:30 Coffee
8:30 - 8:40 Welcome
Claude Lenfant, Director, NHLBI
Michael C. Lin, Coordinator, NHLBI
8:40 - 9:10 NIH Perspectives
Stephen Straus, Director, NCCAM
Paul Coates, Director, ODS
9:10 - 9:40 FDA Perspectives
Shaw Chen, FDA
Session I: Garlic Chair: Eric Block
Introduction and Chemistry
9:40 - 10:10 Introduction and Overview
Eric Block, State University of New York at Albany
10:10 - 10:30 Coffee Break
10:30 - 11:00 Biochemical Mechanism of Effect of Garlic
Larry Lawson, Plant Bioactives Research Institute
Mechanisms of Action and Animal Studies
11:00 - 11:30 Effect of Garlic on Biosynthesis and Serum Levels of Cholesterol
Rolf Gebhardt, University of Leipzig, Germany
11:30 - 12:00 Effect of Garlic in Animal Models
Jose Pedraza-Chaverri, Ciudad University, Mexico
12:00 - 12:30 Effect of Garlic on Lipid Metabolism
Gunter Siegel, Free University of Berlin, Germany
12:30 - 1:30 Lunch Break
1:30 - 2:00 Discussion
Clinical Studies
2:00 - 2:30 Clinical Trials
Christopher Gardner, Stanford University
2:30 - 3:00 Interactions of Botanicals and Cardiovascular Drugs
Adrian Fugh-Berman, Georgetown University
3:00 - 3:30 Discussion
3:30 - 3:50 Coffee Break
Session II: Ginkgo Biloba Chair: Curt D. Furberg, Wake Forest University
3:50 - 4:20 Vascular Effects
John Farquhar, Stanford University
4:20 - 4:50 Clinical Studies
Jeff Williamson, Wake Forest University
4:50 - 5:20 Discussion

Friday, August 23, 2002

8:00 - 8:30 Coffee
Session III: Flavonoid-containing Botanicals Chair: Curt D. Furberg
8:30 - 9:00 Cardiovascular Protection: The Role of Alcohol and Red Wine Polyphenols
Dale Parks, University of Alabana at Birmingham
9:00 - 9:30 Hawthorn Flavonoids
Keith Aaronson, University of Michigan
9:30 - 10:00 Discussion
10:00 - 10:30 Cardiovascular Effect of Soy Phytoestrogen: Pre-clinical Studies
Thomas Clarkson, Wake Forest University
10:30 - 10:50 Coffee Break
10:50 - 11:20 Phytoestrogen Clinical Studies
Greg Burke, Wake Forest University
11:20 - 11:50 Discussion
11:50 - 12:30 Conclusion & Recommendations