Bethesda North Marriott Hotel & Conference Center, Bethesda, MD
| 7:30 - 8:00 | Registration and Continental Breakfast |
| 8:00 - 8:15 | Welcome
Paul M. Coates, Director, Office of Dietary Supplements |
Round Table Introductions
John H. Cardellina II, Office of Dietary Supplements |
Charge to speakers and observers
Joseph M. Betz, Office of Dietary Supplements |
| 8:15 - 8:35 | Why vitamin D?
Mary Frances Picciano, Office of Dietary Supplements |
Opening Session: |
| 8:35 - 8:55 | Vitamin D Chemistry and metabolites
Hector DeLuca, University of Wisconsin |
| 8:55 – 9:15 | The significance of 3-epi-25-hydroxyvitamin D2 and 3-epi-25-hydroxyvitamin D3
in clinical measurements of vitamin D exposure
G. Satya Reddy, Brown University |
| 9:15 – 9:35 | In an ideal world, we'd be counting molecules
Stephen Barnes, University of Alabama at Birmingham |
| 9:35 - 10:15 | Discussion |
| 10:15 - 10:45 | Mid-morning Break |
Session 1: General Principles of Measurement Science |
| 10:45 - 11:25 | Fitness for purpose, accuracy, and precision. Establishing the "trueness" of
analytical measurements, evaluating reliability of the method, and determining inherent variability of the method
Mark Roman, Tampa Bay Analytical Research, Inc. |
| 11:25 - 11:45 | Reference materials for clinical measurands: the importance of commutability
John H. Eckfeldt, University of Minnesota |
| 11:45 - 12:15 | Discussion |
| 12:15 - 1:30 | Lunch (on your own) |
Session 2: Analytical Approaches to Nutrient Measurement |
| 1:30 - 1:50 | Physical and bioorganic principles of antigen/antibody measurements and
measurement implications - Accuracy, Precision, Specificity
Gyorgy Abel, Director, Lahey Clinic |
| 1:50 - 2:10 | Physical and bioorganic principles of chromatographic measurements using
spectrophotometric/spectrometric detection - Accuracy, Precision, Specificity
Craig Byrdwell, USDA, ARS, BHNRC, FCMDL |
| 2:10 - 2:30 | Assessment of available analytical methods for vitamin D measurement in biological fluids
Graham D. Carter, DEQAS Organizer, Imperial College Healthcare, London |
| 2:30 - 2:50 | Standard Reference Materials for vitamin D measurement in biological fluids
Karen Phinney, NIST |
| 2:50 – 3:20 | Discussion |
| 3:20 - 3:40 | Mid-Afternoon Break |
Closing Session: |
| 3:40 - 4:00 | Approaches to reconciling measurement methods based on different physical/chemical principles
Linda Thienpont, University of Ghent, Belgium |
| 4:00 - 4:20 | Discussion |
| 4:20 - 5:00 | Summary and identification of action items: knowledge gaps, and suggested
research agenda for future studies |
| 5:00 – 5:30 | Public Comment |
| 5:30 PM | Adjourn |