Carnitine the Science Behind an Essential Nutrient
March 25-26 2004 National Institutes of Health Bethesda, Maryland
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Agenda

Thursday, March 25, 2004

An Adobe Acrobat PDF* file of the speakers' presentations can be found by clicking on the title of their talk.

8:30 am Registration and Continental Breakfast

9:00 am Opening Remarks
 

Owen M. Rennert, Scientific Director, NICHD, NIH
Marc R. Blackman, Scientific Director for Clinical Research, NCCAM, NIH (PDF, 132 KB)

Plenary Session I: The Carnitine System in Human Metabolism
Chair: Marc R. Blackman, Scientific Director for Clinical Research, NCCAM, NIH

9:20 am The Role of the Carnitine System in Human Metabolism
  Daniel W. Foster (PDF, 913 KB)
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

10:20 am

Break

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SESSION 1: CARNITINE PHYSIOLOGY AND PHARMACOLOGY: THE BASICS
Chair: Marc R. Blackman, Scientific Director for Clinical Research, NCCAM, NIH

10:35 am Structure and Function of Carnitine Acyltransfrases
 

Liang Tong (PDF, 1 MB)
Movie 1 (Quicktime, 4 MB)
Movie 2 (Quicktime, 5 MB)
Department of Biological Sciences, Columbia University, New York, New York

11:05 am Overview of Physiological and Pharmacological Actions
  Charles J. Rebouche (PDF, 984 KB)
Associate Professor, Department of Pediatrics, University of Iowa, Iowa City, Iowa

SESSION 2: CARNITINE REPLACEMENT
Chair: Paul Coates, Director, Office of Dietary Supplements (ODS), NIH, Bethesda, Maryland

11:35 am Carnitine Deficiency Disorders in Children
  Charles Stanley (PDF, 181 KB)
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

12:05 pm Lunch (lunch vouchers for Bldg. 45 cafeteria for non-federal attendees; federal attendees on own for lunch)

1:30 pm Carnitine Replacement in End-Stage Renal Disease and Hemodialysis
  Menotti Calvani (PDF, 1.5 MB)
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Rome, Italy

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SESSION 3: CARNITINE EFFECTS ON MUSCLE: SKELETAL, CARDIAC, OR SMOOTH
Chair: Rebecca Costello, Deputy Director, Office of Dietary Supplements (ODS), NIH, Bethesda, Maryland

2:00 pm Carnitine and Sports Medicine: Use or Abuse?
  Eric P. Brass (PDF, 113 KB)
Center for Clinical Pharmacology, Department of Medicine, Harbor-UCL, Torrance, California

2:30 pm Therapeutic Effects of L-Carnitine and Propionyl-L-Carnitine on Cardiovascular Diseases: A Review
  Roberto Ferrari (PDF, 3.4 MB)
Cattedra di Cardiologia, Universitá degli Studi di Brescia, Brescia, Italy

3:00 pm Carnitine and Peripheral Arterial Disease
  William R. Hiatt (PDF, 493 KB)
University of Colorado Health Sciences Center, Denver, Colorado

3:30 pm Break


SESSION 4: CARNITINE, FAT METABOLISM AND OBESITY
Chair: Michael J. Quon, Chief, Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, NIH, Bethesda, Maryland

3:45 pm Carnitine in Type 2 Diabetes
  Geltrude Mingrone (PDF, 1.27 MB)
Istituto di Medicina Interna, Catholic University, Roma,Italy

4:15 pm Adjourn

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Friday, March 26, 2004

Plenary Session II: Carnitine and Acyl-Carnitines In Aging
Chair: Husseini Manji, Director, Molecular Pathology, National Institute of Mental Health (NIMH), NIH, Bethesda, Maryland

8:30 am Registration and Continental Breakfast

9:00 am Delaying the Mitochondrial Decay of Aging With Acetyl Carnitine 
  Bruce N. Ames (PDF, 1.12 MB)
University of California, Berkeley, California

10:00 am Break


SESSION 5: CARNITINE, IMMUNITY, AND HIV INFECTION
Chair: Carlos Zarate, NIMH, NIH, Bethesda, Maryland

10:15 am Immunomodulatory Properties of Carnitine
  Claudio De Simone (PDF, 578 KB)
Department of Experimental Medicine, University of L' Aquila, Rome, Italy

10:45 am Acetyl-L-Carnitine for the Treatment of Lipoatrophy in HIV: Infected Patients Taking Antiretroviral Drugs
  Mariana Gerschenson (PDF, 862 KB)
Division of Heart and Vascular Diseases, NHLBI/NIH, Bethesda, Maryland

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SESSION 6: NEW PERSPECTIVES IN CARNITINE RESEARCH
Chairs: George P. Chrousos, Chief, Pediatrics and Reproductive Endocrinology Branch, NICHD, NIH, Bethesda, Maryland

11:15 am Carnitine, A Nutritional Modulator of the Glucocorticoid Receptor
  Salvatore Alesci (PDF, 702 KB)
CNE/NIMH & PREB/NICHD, NIH, Bethesda, Maryland

11:45 am Effects of Carnitine on Thyroid Hormone Action
  Salvatore Benvenga (PDF, 381 KB)
Cattedra di Endocrinologia, University of Messina School of Medicine, Messina, Italy

12:15 pm Lunch (lunch vouchers for Bldg. 45 cafeteria for non-federal attendees; federal attendees on own for lunch)

1:30 pm Carnitine and Cancer
  Ricardo A. Cruciani (PDF, 123 KB)
Beth Israel Medical Center, Department of Pain Medicine and Palliative Care, New York, New York

2:00 pm Carnitine and Male Infertility
  Marc R. Blackman (PDF, 250 KB)
NCCAM, NIH, Bethesda, Maryland

2:30 pm

L-Carnitine Ameliorates Vascular Dysfunction Caused by Elevated Free Fatty Acids
Helmet Steinberg (PDF, 119 KB)
Indiana University School of Medicine, Indiana

3:00 pm Break

SUMMARY AND FUTURE DIRECTIONS

3:15 pm Panel Discussion
Moderator: George P. Chrousos, NICHD, NIH
Bruce N. Ames Paul Coates
Menotti Calvani Charles Stanley
   


CONCLUDING REMARKS

4:00 pm Paul Coates, ODS, NIH (PDF, 575 KB)

4:15 pm Adjournment

Accreditations
The American College of Nutrition is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

The American College of Nutrition designates this continuing medical education activity for 12.5 CME credit hours in Category 1 of the Physician's Recognition Award of the American Medical Association.

The Certification Board for Nutrition Specialists (CBNS) authorizes 13.5 CNE credits hours for Certified Nutrition Specialists (CNS).

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