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Vitamin D Standardization Program (VDSP) Symposium: Tools to Improve Laboratory Measurement

Agenda — November 14, 2013

8:30 A.M. Welcome

Carlos A. Gonzalez, Ph.D. — Chief, Chemical Sciences Division, NIST
Paul Coates, Ph.D. — Director, Office of Dietary Supplements (ODS), National Institutes of Health (NIH)

Session 1 Vitamin D Laboratory Measurement: Defining the Problem

Moderator: Christopher Sempos, Ph.D. — ODS, NIH

8:45 A.M.

VDSP Overview and Meeting Agenda
Christopher Sempos, Ph.D. — ODS, NIH

9:00 A.M.

Lack of Standardization: Clinical Impact
Neil Binkley, M.D. — University of Wisconsin-Madison

Session 2 The VDSP Reference Measurement System: Initial Results on Interlaboratory Comparison

Moderator: Katleen Van Uytfanghe, Ph.D. — Ghent University

9:15 A.M.

VDSP Reference Measurement System: NIST Components, Current and Future
Stephen Wise, Ph.D. — NIST

9:30 A.M.

Discussants: Donald Walt Chandler, Ph.D. — Laboratory Corporation of America (LabCorp) and Nigel J. Clarke, Ph.D. — Quest Diagnostics

9:45 A.M.

Value Assignment and Uncertainty Evaluation for the Samples Used in the VDSP Interlaboratory and Commutability Studies
Antonio Possolo, Ph.D. — NIST

10:00 A.M.

Break

10:15 A.M.

VDSP Reference Measurement System: Vitamin D Standardization Certification Program (VDSCP) and Interlaboratory Comparison Study Results
Hubert Vesper, Ph.D. — Centers for Disease Control and Prevention (CDC)

10:40 A.M.

Discussants: James Freeman, Siemens Healthcare and Andre Valcour, Ph.D. — LabCorp

11:00 A.M.

Open Discussion

Session 3 The VDSP Reference Measurement System: External Quality Assessment/Proficiency Testing (EQA/PT) Programs and Commutability

Moderator: Gary Myers, Ph.D. — American Association for Clinical Chemistry (AACC)

11:15 A.M.

Why Commutability Matters
Gary Myers, Ph.D. — AACC

11:30 A.M.

VDSP Commutability Study Results
Karen W. Phinney, Ph.D. — NIST

11:45 A.M.

VDSP Reference Measurement System: The Role of Accuracy-Based EQA/PT Schemes
Graham Carter — Imperial College Healthcare, Charing Cross Hospital, Vitamin D External Quality Assessment Scheme (DEQAS)

12:00 NOON

NIST Value Assignment of DEQAS Samples
Johanna Camara, Ph.D. — NIST

12:10 P.M.

College of American Pathologists (CAP) Accuracy-Based Vitamin D (ABVD) Survey
Andrew Hoofnagle, M.D., Ph.D. — University of Washington and CAP

12:20 P.M.

NIST-NIH Vitamin D Metabolites Quality Assurance Program (VitDQAP)
Mary Bedner, Ph.D. — NIST

12:30 P.M.

Discussants: Ronald L. Horst, Ph.D. — Heartland Assays, LLC and Joshua Soldo — DiaSorin, Inc.

12:45 P.M.

Open Discussion

1:00 P.M.

Lunch Break

Session 4 Impact of Standardization and VDSP Assessment

Moderator: Robyn Lucas, M.B.Ch.B., Ph.D. — The Australian National University

2:15 P.M.

Standardizing Past 25(OH)D National Survey Data: The Irish Experience and Implications for Re-assessing Vitamin D Requirements in Europe
Kevin Cashman, Ph.D. — University College Cork

2:30 P.M.

Standardizing Past 25(OH)D National Survey Data: The Impact of Standardization on the Interpretation of Data from the Canadian Health Measures Survey
Stephen Brooks, Ph.D. — Health Canada

2:45 P.M.

Discussant: Public Health Impact of Standardization
Robyn Lucas, M.B.Ch.B., Ph.D. — The Australian National University

3:00 P.M.

Discussants: Standardizing Old Research Data: Importance to Clinical Research
Daniel D. Bikle, M.D., Ph.D. — University of California San Francisco and Neil Binkley, M.D. — University of Wisconsin-Madison

3:15 P.M.

Open Discussion

3:30 P.M.

Break

Session 5 VDSP So Far and Plans for the Future

Moderator: Ian Young, M.D., Ph.D. — Royal Victoria Hospital, Belfast, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)

4:00 P.M.

VDSP So Far and Plans for the Future
Christopher Sempos, Ph.D. — ODS, NIH

4:15 P.M.

Open Discussion with VDSP Panelists

  • Christopher Sempos, Ph.D. — ODS, NIH
  • Stephen Wise, Ph.D. — NIST
  • Katleen Van Uytfanghe, Ph.D. — Ghent University
  • Hubert Vesper, Ph.D. — CDC
  • Graham Carter — Imperial College Healthcare, Charring Cross Hospital, DEQAS
  • Andrew Hoofnagle, M.D., Ph.D. — University of Washington and CAP
4:45 P.M.

Discussant: Ian Young, M.D., Ph.D. — Royal Victoria Hospital, Belfast, IFCC

5:00 P.M.

Closing Comments

5:15 P.M.

Adjourn

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