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Evidence-Based Review Program

Description
Completed Evidence Reports
Recently Completed Reports
Full List of Evidence Reports & Publications

Description

In FY 2001, the NIH Office of Dietary Supplements (ODS) received a Congressional mandate to review the current scientific evidence on the efficacy and safety of dietary supplements and identify research needs. ODS responded by developing an evidence-based review program using the Evidence-based Practice Centers Program established by the Agency for Healthcare Research and Quality (AHRQ) to conduct systematic reviews of the scientific literature and prepare reports of their findings.

Completed Evidence Reports

ODS, in collaboration with other NIH institutes and centers, has found these reports invaluable in presenting what is and is not known in a research area, thus laying a sound foundation for identifying gaps in knowledge and providing a strong scientific basis for the development of a research agenda.

ODS-sponsored evidence reports have resulted in the publication of a number of articles in the peer-reviewed literature, and have helped NIH make decisions on research priorities in these areas. The reports and associated publications are available through the links above by topic.

Recently Completed Reports

ODS sponsored an evidence report on the Effectiveness and Safety of Vitamin D that will be used by the Vitamin D Federal Working Group in establishing a research agenda to answer important public health questions about vitamin D. The reportexternal link icon was published in August 2007. This report was the basis of a conference on the NIH campus, September 5-6, 2007, Vitamin D and Health in the 21st Century: An Updateexternal link icon, with the goal of presenting a balanced overview of the available evidence on the efficacy and safety of vitamin D as an update to the 2003 ODS Conference on Vitamin D and Bone Health. Proceedings from the conference will be published in the American Journal of Clinical Nutrition in the spring of 2008.

Full List of Evidence Reports & Publications

B Vitamins and Berries

Evidence Report
Balk E, Chung M, Raman G, Tatsioni A, Chew P, Ip S, DeVine D, Lau J. B Vitamins and Berries and Age-Related Neurodegenerative Disordersexternal link icon. Evidence Report/Technology Assessment No. 134. (Prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022). AHRQ Publication No. 06-E008. Rockville, MD: Agency for Healthcare Research and Quality. April 2006.

Associated Publication
Raman G, Tatsioni A, Chung M, Rosenberg IH, Lau J, Lichtenstein AH, Balk EM. Heterogeneity and Lack of Good Quality Studies Limit Association Between Folate, Vitamins B-6 and B-12, and Cognitive Functionexternal link icon. J Nutri. 2007 July;137(7):1789-1794.

Ephedra

Evidence Report
Shekelle P, Morton S, Maglione M, et al. Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effectsexternal link icon. Evidence Report/Technology Assessment No. 76 (Prepared by Southern California Evidence-based Practice Center, RAND, under Contract No 290-97-0001). AHRQ Publication No. 03-E022. Rockville, MD: Agency for Healthcare Research and Quality. March 2003.

Associated Publication
Shekelle P, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne,J. Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: A Meta-analysisexternal link icon. JAMA, 2003 Mar 26; 289 (12) 1537 45. Epub 2003 Mar 10.

Related Information on Ephedra

Multivitamin/Mineral Supplements

Evidence Report
Huang HY, Cabellero B, Chang S, Alberg A, Semba R, Schneyer C, Wilson RF, Cheng TY, Prokopowicz G, Barnes GJ, Vassy J, Bass EB. Multivitamin/Mineral Supplements and Prevention of Chronic Diseaseexternal link icon. Evidence Report/Technology Assessment No. 139. (Prepared by The Johns Hopkins University Evidence-based Practice Center under Contract No. 290-02-0018). AHRQ Publication No. 06-E012. Rockville, MD: Agency for Healthcare Research and Quality. May 2006.

Associated Publications
Huang HY, Cabellero B, Chang S, Alberg AJ, Semba RD, Schneyer CR, Wilson RF, Cheng TY, Vassy J, Prokopowicz G, Barnes J, Bass EB. Mulltivitamin/Mineral supplements and prevention of chronic disease: executive summaryexternal link icon. Am J Clin Nutr. 2007 Jan;85(1):265S-268S. No abstract available.

Huang HY, Cabellero B, Chang S, Alberg AJ, Semba RD, Schneyer CR, Wilson RF, Cheng TY, Vassy J, Prokopowicz G, Barnes J, Bass EB. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conferenceexternal link icon. Ann Intern Med, 2006 Sep 5; 145(5):372-85. Epub 2006 Jul 31.

Related Information on Multivitamins/Mineral Supplements

Omega-3 Fatty Acids

Related Information on Omega-3 Fatty Acids

Soy

Evidence Report
Balk E, Chung M, Chew P, Ip S, Raman G, Kupelnick B, Tatsioni A, Sun Y, Wolk B, DeVine D, Lau J. Effects of Soy on Health Outcomesexternal link icon. Evidence Report/Technology Assessment No. 126. (Prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022.) AHRQ Publication No. 05-E024-2. Rockville, MD: Agency for Healthcare Research and Quality. August 2005.

Vitamin D

Evidence Reports
Cranney A, Horsely T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garrity C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Effectiveness and Safety of Vitamin D in Relation to Bone Healthexternal link icon. Evidence Report/Technology Assessment No. 158. (Prepared by Ottawa Evidence-based Practice Center under Contract No. 290-02-0021). AHRQ Publication No. 07-E013, Rockville, MD: Agency for Healthcare Research and Quality. August 2007.

Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, Lichtenstein A, Patel K, Raman G, Tatsioni A, Terasawa T, Trikalinos TA. Vitamin D and Calcium: Systematic Review of Health Outcomesexternal link icon. Evidence Report/Technology Assessment No. 183. (Prepared by Tufts Evidence-based Practice Center under Contract No. 290-2007-10055-1). AHRQ Publication No. 09-E015, Rockville, MD: Agency for Healthcare Research and Quality. August 2009.

Associated Publication
Chung M, Balk EM, Ip S, Lee J, Terasawa T, Raman G, Trikalinos T, Lichtenstein A, Lau J. Systematic review to support the development of nutrient reference intake values: challenges and solutionsexternal link icon. Am J Clin Nutr. First published ahead of print May 26, 2010 as doi: 10.3945/ajcn.2009.29092.