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Grant Abstract: FeverPhone: Point of Care Diagnosis of Acute Febrile Illness using a Mobile Device

Grant Number: 5R01EB021331-04
PI Name: Erickson
Project Title: FeverPhone: Point of Care Diagnosis of Acute Febrile Illness using a Mobile Device

Abstract: Dietary supplement use can potentially affect the risk of infection and related outcomes. The proposed research seeks to understand the relationships between dietary supplement use and the metabolic and immune response in the context of infection. Nutritional deficiencies and acute febrile illness contribute substantially to the burden of disease in resource limited settings. The proposed research will address gaps in how dietary supplement use relates to infection severity and outcome. Our goal is to better understand the role of dietary supplements in disease risk, vulnerability, and outcome to ultimately advance research in nutrition, metabolomics, and immunopathology. As part of a parent R01 award, we are collecting detailed information on demographics, medical history, clinical symptoms, home environment, dietary recall, and dietary supplement use as well as blood specimens from 300-500 consenting clinical participants who present to hospital with symptoms of acute febrile illness. Participants attend acute and convalescent study visits, and confirmatory infectious disease diagnostics are included in the parent study. The supplement research proposes to measure a comprehensive panel of nutrient status, inflammation, immune response, and metabolite biomarkers in stored serum specimens of participants and analyze the resulting data for associations stratified by dietary supplement use. By conducting basic and translational research on dietary supplements in the pathobiology, prevention, and treatment of infection, we aim to inform both clinical care and public health programs for best practices. In addition, this work will also inform the design and development of our personalized diagnostics platform, the focus of the parent R01 award.

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