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Grant Abstract: Circadian rhythms and cardiovascular risk

Grant Number: 5R01HL125893-03
PI Name: Shea
Project Title: Circadian rhythms and cardiovascular risk

Abstract: We now plan to test the efficacy of Vitamin C to counteract morning CV risk markers in a randomized, double blind, placebo controlled crossover study. The participants will also perform morning typical behaviors such as arousal from sleep, change in posture (getting out of bed) and mild intensity physical activity; identical to the stressors tested in our parent R01. This is a pilot study in healthy middle aged adults without a history of CV disease, but who may be at increased risk for CV disease based on low ascorbate levels (66), and age alone.

We have one specific aim:
Aim 1: To test the efficacy of oral Vitamin C to reduce oxidative stress and improve vascular endothelial function across the morning in healthy middle aged adults. We hypothesize that as compared to placebo, Vitamin C will reduce oxidative stress and improve vascular endothelial function. Furthermore, by reducing oxidative stress, Vitamin C will improve downstream CV risk markers such as platelet aggregability, and plasminogen activator inhibitor-1.


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