The National Institute of Standards and Technology (NIST) has developed Standard Reference Materials for bitter orange, an ingredient found in certain dietary supplement products. Researchers can use the new materials to develop and test analytical methods for compounds in bitter orange or as control materials for quality assurance. The new bitter orange reference materials include SRM 3258 (ground fruit), SRM 3259 (extract) and SRM 3260 (solid oral dosage form). In addition, the three SRMs are packaged together as SRM 3261. The SRM materials for analysis and measurement come with certified concentration values for synephrine, octopamine, tyramine, N-methylytramine, hordenine, total alkaloids and caffeine. The SRMs for bitter orange can be found on the NIST Web site at
https://www-s.nist.gov/srmors/view_detail.cfm?srm=3261
.
Partial support for the development of the bitter orange SRMs was provided by the NIH Office of Dietary Supplements and the U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER). For more information on these and other NIST Standard Reference Materials, see Technology Services: Standard Reference Materials at
http://www.nist.gov/srm.