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Dietary Supplement Use in the Elderly, January 14-15, 2003

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Dietary Supplement Use in the Elderly

January 14-15, 2003

Natcher Auditorium

Natcher Conference Center, Building 45

Bethesda, MD 20892

[ Conference Agenda |
Sponsors and Partners |
Travel Awardees ]


Tuesday, January 14, 2003
7:30 a.m. - 8:30 a.m.Continental Breakfast and Registration
8:30 a.m. - 8:50 a.m.Welcome

Judith Finkelstein, Head, Office of Nutrition, National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD

Richard Hodes, Director, NIA, NIH, Bethesda, MD

Paul Coates, Director, Office of Dietary Supplements, NIH, Bethesda, MD
8:50 a.m. - 9:30 a.m.Introduction to the Conference

Robert Russell, Conference Chair, Director and Senior Scientist,

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University

Nancy Wellman, Honorary Chair, Professor and Director, National Policy and Resource Center on Nutrition and Aging, Florida International University

Keynote Address

Martin T. Gahart, Ph.D.

Assistant Director, Health Care, U.S. General Accounting Office
GAO Review: Health Products for Seniors


PLENARY SESSION I: Overview of Dietary Supplements

 Focus: An overview of the universe of dietary supplements currently marketed to the elderly, possible justification based on national survey data, and history of use both in the United States.

Session Chair:

Rebecca Costello, Deputy Director, Office of Dietary Supplements, NIH, Bethesda, MD
(Speaker Presentations: 20 minutes; Questions & Answers: 5 minutes)
9:30 a.m. - 9:55 a.m. Ethnic, Demographic, and Lifestyle Determinants of Dietary Supplement Use in the Elderly

Katherine Tucker, Tufts University
9:55 a.m. - 10:20 a.m.Ethnic, Demographic, and Lifestyle Determinants of Dietary Supplement Use in the Elderly

Suzanne Murphy, University of Hawaii
10:20 a.m. - 10:35 a.m.Break
10:35 a.m. - 11:00 a.m. Behavioral/Social/Cultural Factors That Determine Dietary Supplement Use in the Elderly

Pam Haines, University of North Carolina at Chapel Hill, Chapel Hill, NC
11:00 a.m. - 11:25 a.m.Role of Nutrition in Maintaining the Health in the Nation's Elderly: Overview from the Institute of Medicine Reports

Virginia A. Stallings, The Children's Hospital of Philadelphia, Philadelphia, PA
11:25 a.m. - 12:00 noonPANEL DISCUSSION I

Ronni Chernoff, VA GRECC, Little Rock, AR

Annette Dickinson, Council for Responsible Nutrition

Jeanne Goldberg, Tufts University

Jean Lloyd, Administration on Aging

Panel Questions:
  1. How can we design studies that will best be able to determine DS usage in the elderly (e.g. large national surveys, small local samples, specific groups)?
  2. What types of study designs would facilitate more effective interventions to modify dietary supplement use to be more aligned with the science?
  3. What behavioral characteristics and attitudes determine why the elderly use DS, and what type of DS is used?
  4. What are the three to five most critical research needs in this area?

12:00 noon - 1:00 p.m.Boxed Lunches

PLENARY SESSION II: Special Issues of the Aging Population

 Focus: Discussion of specific needs of the elderly in relation to age-related alterations in physiology, during periods of chronic disease and in different demographic and/or geographic settings. Identification of factors (e.g., bioavailability, to be considered in the evaluation safety and efficacy of dietary supplements, and how these factors might change with levels of health and wellness).

Session Chair:

John Milner, Chief, Nutritional Science Research Group, National Cancer Institute (NCI), NIH, Bethesda, MD

(Speaker Presentations: 20 minutes; Questions & Answers: 5 minutes)
1:00 p.m. - 1:25 p.m.Overview of Age-Related Changes in Physiology

Tammy Harris, NIA, NIH, Bethesda, MD
1:25 p.m. - 1:50 p.m.Overview on Age-Related Endocrine Changes and the Role of Supplementation (Including Anti-Aging Hormonal Supplements: Growth Hormone, Melatonin, DHEA)
Marc Blackman, Director of Intramural Research, National Center for Complementary and Alternative Medicine, NIH, Bethesda, MD
1:50 p.m. - 2:15 p.m.Polypharmacy and OTCs: What is the Impact of Dietary Supplements on Gene Networks that Regulate Drug Clearance?

Barry Marc Forman, Beckman Research Institute, Duarte, CA
2:15 p.m. - 2:40 p.m.Caution in High-Dose Supplement Use: A Case Study of B-Carotene

Robert M. Russell, Tufts University
2:40 p.m. - 3:05 p.m.Tamoxifen and Soybean Isoflavones and Soyfoods: Are there clinically Relevant Interactions?

Mark Messina, Nutrition Matters, Inc.
3:05 p.m. - 3:20 p.m.Break
3:20 p.m. - 3:45 p.m.Importance of Vitamin D in the Prevention of Osteoporosis, Prostate, Colon, and Breast Cancer, Hypertension and Heart Disease and Type I Diabetes

Michael Holick, Boston University Medical Center, Boston, MA
3:45 p.m. - 4:10 p.m.The Metabolic Tune up and Disease Prevention

Bruce Ames, Children's Hospital, Oakland, CA
4:10 p.m. - 4:35 p.m.Application of Computers, Bioinformatics, and Modeling To Predict Effectiveness and Safety of Dietary Supplements

Herbert S. Rosenkranz, University of Pittsburgh, Pittsburgh, PA
4:35 p.m. - 5:10 p.m.PANEL DISCUSSION II

Joseph T. Hanlon, University of Minnesota

David Kroll, National Products Laboratory, Research Triangle Institute

Leila G. Saldanha, Consumer Healthcare Products Association

Gary Williams, New York Medical College, Valhalla, NY

Panel Questions:
  1. What DS are used for both prevention and therapy?
  2. What types of new methodologies can be applied to determining safety and effectiveness of DS (e.g., modeling), and how can they take into account the special characteristics of the elderly?
  3. How are individual differences, which are particularly evident in research on the elderly, taken into account in explaining the interactions of DS with disease states, prescription medications, genetic factors, and environmental exposures?
  4. What are the three to five most critical research needs in this area?

5:10 p.m. - 5:30 p.m.Group photos for speakers and travel awardees
5:10 p.m.Adjournment (dinner on your own)
Wednesday, January 15, 2003

PLENARY SESSION III: Evidence-Based Studies

Focus: Evidence-based studies will be presented with regard to healthy aging and disease prevention. The many challenges posed in gathering data in this area include: defining subject/patient populations, optimizing the experimental design, identifying appropriate biomarkers, understanding genetic variability, and developing appropriate animal models.

Session Chair:

Judy Salerno, Deputy Director, NIA, NIH, Bethesda, MD
8:30 a.m. - 9:10 a.m.Application of Evidence to Decision Making

Barnett S. Kramer, Director, Office of Disease Prevention, NIH, Bethesda, MD

(Speaker Presentations: 20 minutes; Questions & Answers: 5 minutes)
9:10 a.m. - 9:35 a.m.Reviewing the Evidencebase for Supplemental Antioxidant Nutrients and Cancer Prevention: What We've Learned

Susan Mayne, Yale University
9:35 a.m. - 10:00 a.m.What is the Evidence for Supplement Use for Menopausal Symptoms?

Gail B. Mahady, University of Illinois-Chicago, Chicago, IL
10:00 a.m. - 10:15 a.m.Break
10:15 a.m. - 10:40 a.m.What Is the Strength of the Evidence for Supplement Use for Healthy Cognitive Function? (vitamins, folate, gingko)

Carl Cotman, University of California at Irvine, Irvine, CA
10:40 a.m. - 11:05 a.m.Use of Antioxidant Vitamins and Minerals in Age-related Eye Diseases

Emily Chew, National Eye Institute, NIH, Bethesda, MD
11:05 a.m. - 11:30 a.m.Vitamin Supplements and Cardiovascular Disease

Howard N. Hodis, USC
11:30 a.m. - 11:55 a.mWhat Is the Evidence for Supplement Use for Healthy Bones?

Bess Dawson-Hughes, Tufts University
11:55 a.m. - 12:55 p.m.Boxed Lunch

Session Chair:

Judith Finkelstein, Head Office of Nutrition, NIA, NIH, Bethesda, MD
12:55 p.m. - 1:20 p.m.What Is the Strength of the Evidence for Supplement Use for a Healthy Immune System? (Echinacea, vitamin E, zinc, omega-3 fatty acids)

Gabriel Fernandes, University of Texas Health Science Center, San Antonio, TX
1:20 p.m. - 1:45 p.mEvaluating Benefits and Risks of Dietary Supplement Use in the Elderly: The Perspective of the Food and Drug Administration (FDA). What Type of Scientific Data Can NIH Provide to Address This Issue?

Beth Yetley, Food and Drug Administration, Rockville, MD
1:45 pm. - 2:30 p.m.PANEL DISCUSSION III

Flint Beal, Cornell University Medical College, New York, NY

Steve Dentali, American Herbal Products

Julie Mares-Perlman, University of Wisconsin, Madison, WI

Mark Mattson, NIA Intramural, NIH, Bethesda, MD

Irv Rosenberg, Tufts University

Panel Questions:
  1. What types of clinical studies (small, large) are still needed to answer questions about the efficacy of supplements?
  2. Can the populations in existing epidemiological studies be utilized to answer questions about the "who, where, what, and why" of dietary supplement use in the elderly?
  3. What evidence is required from studies on experimental animals, in cell systems, and at the molecular and genetic levels to provide insight into mechanisms of action of dietary supplements in the elderly?
  4. What are the three to five most critical research needs in this area?

2:30 p.m. - 2:45 p.m.Summary and Closing Remarks
2:45 p.m.Adjourn