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Mechanistic Studies of Cardiovascular Effects of Botanicals

Sponsored by: National Heart, Lung and Blood Institute
Office of Dietary Supplements
National Center for Complementary and Alternative Medicine

August 22-23, 2002
Bethesda, MD

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Conference Goals:

• Assess the current state of research on the mechanisms of action responsible for the cardiovascular effect of several widely-used herbal dietary supplements, including garlic, ginkgo, hawthorn and phytoestrogens and the evidence for their clinical efficacy.
• Develop recommendations to identify research opportunities and to discuss potential clinical use of botanicals.
• Promote exchange of information and ideas, identify opportunities and foster collaboration among scientists who are interested in using botanicals in cardiovascular research.

Agenda:

Thursday, August 22, 2002
8:00 - 8:30	Coffee
8:30 - 8:40	Welcome Claude Lenfant, Director, NHLBI Michael C. Lin, Coordinator, NHLBI
8:40 - 9:10	NIH Perspectives Stephen Straus, Director, NCCAM Paul Coates, Director, ODS
9:10 - 9:40	FDA Perspectives Shaw Chen, FDA
Session I: Garlic	Chair: Eric Block
Introduction and Chemistry
9:40 - 10:10	Introduction and Overview Eric Block, State University of New York at Albany
10:10 - 10:30	Coffee Break
10:30 - 11:00	Biochemical Mechanism of Effect of Garlic Larry Lawson, Plant Bioactives Research Institute
Mechanisms of Action and Animal Studies
11:00 - 11:30	Effect of Garlic on Biosynthesis and Serum Levels of Cholesterol Rolf Gebhardt, University of Leipzig, Germany
11:30 - 12:00	Effect of Garlic in Animal Models Jose Pedraza-Chaverri, Ciudad University, Mexico
12:00 - 12:30	Effect of Garlic on Lipid Metabolism Gunter Siegel, Free University of Berlin, Germany
12:30 - 1:30	Lunch Break
1:30 - 2:00	Discussion
Clinical Studies
2:00 - 2:30	Clinical Trials Christopher Gardner, Stanford University
2:30 - 3:00	Interactions of Botanicals and Cardiovascular Drugs Adrian Fugh-Berman, Georgetown University
3:00 - 3:30	Discussion
3:30 - 3:50	Coffee Break
Session II: Ginkgo Biloba	Chair: Curt D. Furberg, Wake Forest University
3:50 - 4:20	Vascular Effects John Farquhar, Stanford University
4:20 - 4:50	Clinical Studies Jeff Williamson, Wake Forest University
4:50 - 5:20	Discussion
Friday, August 23, 2002
8:00 - 8:30	Coffee
Session III: Flavonoid-containing Botanicals	Chair: Curt D. Furberg
8:30 - 9:00	Cardiovascular Protection: The Role of Alcohol and Red Wine Polyphenols Dale Parks, University of Alabana at Birmingham
9:00 - 9:30	Hawthorn Flavonoids Keith Aaronson, University of Michigan
9:30 - 10:00	Discussion
10:00 - 10:30	Cardiovascular Effect of Soy Phytoestrogen: Pre-clinical Studies Thomas Clarkson, Wake Forest University
10:30 - 10:50	Coffee Break
10:50 - 11:20	Phytoestrogen Clinical Studies Greg Burke, Wake Forest University
11:20 - 11:50	Discussion
11:50 - 12:30	Conclusion & Recommendations