Assess factors affecting and current options for improving vitamin D status of women, infants, and children in the United States and internationally.
Vitamin D is an essential nutrient that is unique, both in terms of its metabolism/physiology, and the human reliance on both endogenous production and exogenous sources to meet biological requirements. Recently, evidence has been published indicating a re-emergence of vitamin D-deficient rickets among children. Research has also noted an alarming prevalence of low vitamin D blood levels among all ages in the United States, which may be related to other diseases, such as breast cancer, weakened immunity, and a host of other diseases. Until the revelation of these data, it was assumed that Vitamin D deficiency was no longer a significant health problem and that the successful national food fortification program served as a role model of public health intervention.
As a result of this conference, a focused research program that will provide data essential for the promulgation of evidence-based public policy about achieving vitamin D adequacy in the United States and elsewhere is being put into place.
Abstracts can now be downloaded from the search results page of the Computer Access to Research on Dietary Supplements (CARDS) Database . This feature was added to help users more easily access information on active dietary supplement research trials.
The abstracts can be downloaded in three different file types: plain text, MS Word or HTML. Just click the "ADD" icon and then "Update List" from either the main search results page or from the abstract page. Once abstracts have been added to the list, they may be viewed and downloaded in the file format of the user's choice.
CARDS FY 2002 data are expected to be available to the public on December 19, 2003. There are 571 Dietary Supplement related projects in FY 2002, bringing the total number of projects in the CARDS database to 1751.
The International Bibliographic Information on Dietary Supplements (IBIDS) database has a new team leader, professional librarian Jenifer Kirin.
Ms. Kirin has extensive medical and health reference research and database experience. Previously, she worked as a medical research librarian for the American College of Cardiology and Howard Hughes Medical Center. The IBIDS team is excited to have Ms. Kirin on board to manage the large database, which now contains over 700,000 bibliographies.
ODS-Supported Botanical Research Centers Advance Evidence Base
NIH currently supports six Dietary Supplement Research Centers focused on botanicals. Funding is provided by the Office of Dietary Supplements, National Center for Complementary and Alternative Medicine, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, and the Office of Research on Women's Health.
The six university-based centers are located at:
University of Missouri
Following are selected publications from each of the centers:
Kraus GA, Bae J. Synthesis of undeca-2E-en-8,10-diynoic Isobutylamide. A Novel Constituent of Echinacea angustifolia. Tetrahedron Lett 2003;44: 5505.
Wills NJ, Park J, Wen S, Kesavan GA, Kraus GA, Petrich JW, Carpenter S. Tumor cell cytoxicity of hypericin and related analogs. Photochem Photobiol 2001;74:216-220.
Pfeiffer E., Hohle S, Solyom AM, Metzler M. Studies on the stability of turmeric constituents. J of Food Engineering 2003;56:257-259.
Lantz RC, Chen GJ, Jolad SD, Solyam AM and Timmerman BN. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine (in press).
Morre DJ, Morre DM, Sun H,Cooper R, Chang J and Janle EM. Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX). Pharm & Toxicol 2003;92:234-241.
Prasain JK, Jones K, Kirk M, Wilson L, Smith-Johnson M, Weaver CM, Barnes S. Identification and quantification isoflavonoids in kudzu dietary supplements by HPLC and electraspray ionization tandem mass spectrometry. J Agr Food Chem 2003;51:4213-4218.
Burdette J, Liu J, Chen SN, Fabricant DS, Pierson CE, Barker EL, Pezzuto JM, Mesecar AD, van Breeman RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agri Food Chem 2003;51:5661-5670.
Johnson BM, Qiu S, Zhang S, Zhang F,Burdette JE, Yu L, Bolton JL, van Breeman RB. Identification of electrophilic mammalian metabolites of Piper methysticum Forst (kava). Chem Res Toxicol 2003;16:733-740.
Day JK, Bauer AM, desBordes C, Zhuang Y, Kim B, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang THG, Lubahn DB. Genistein alters DNA methylation patterns in mice. J Nutr 2002; 132:2419S-2423S.
Wang G, Xu J, Rottinghaus GE, Simonyi A, Lubahn DB, Sun GY, Sun AY. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Research 2002;958:439-447.
Sartippour MR, Shao ZM, Heber D, Beatty P, Liu C, Zhang L, Ellis L, Liu W, Go VL, Brooks MN. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr 2002; 132:2307-11.
Dec 9, 1-3pm: Women's Health Research for the 21st Century. Boning Up on Osteoporosis: Emerging Therapies for Prevention and Treatment. (ORWH) - Masur Auditorium.
Dec 18-19, 8-5pm: Selenium Biochemistry 2003: Celebrating 30 Years of Selenoprotein Research. (NHLBI)- Hyatt Regency Bethesda.
Jan 12-13, 2004, 8-5pm: From Clinical Trials to Community: The Science of Translating Diabetes and Obesity Research (NIDDK, OBSSR and CDC) - Natcher Auditorium.
Have a Happy and Safe Holiday Season!
From the Office of Dietary Supplements