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| December 3, 2025 |
ODS Events |
ODS 2025–2026 Seminar Series
The ODS 2025–2026 Seminar Series presents virtual seminars on dietary supplement research and related topics. Intended for those interested in dietary supplement research, the seminars are open to everyone. This month’s seminar kicks off the 2025–2026 Seminar Series.
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December 10, 2025, 11 a.m. ET
Beyond the COSMOS: How hybrid clinical trials of dietary supplements delve deeper into mechanism and efficacy
Howard D. Sesso, Sc.D., MPH, FAHA — Brigham and Women’s Hospital, Harvard Medical School, and Harvard T.H. Chan School of Public Health
Register and view the December seminar flyer to learn more.
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NCCOR Clinical Research Gaps in Pediatric Obesity Pharmacotherapy Workshop
ODS co-planned the National Collaborative on Childhood Obesity Research (NCCOR) workshop, Clinical Research Gaps in Pediatric Obesity Pharmacotherapy, which was held November 3–4 in Atlanta, GA. The purpose of the workshop was to understand current practice and identify research gaps related to prescribing, maintaining, and discontinuing GLP-1 medications and other obesity-related medications for children and adolescents. Next steps include synthesizing ideas, refining questions, and drafting a white paper that outlines prioritized research questions.
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Recently Published ODS Research |
Hooshmand S, Rodriquez EJ, Strassle PD, Mensah GA, Choi K, Hamilton-Moseley KR, George SM, Dwyer-Lindgren L, Mokdad A, Kahn E, Kelly YO, Li Z, Sylte DO, Baumann MM, La Motte-Kerr W, Hinerman A, El-Toukhy S, Pérez-Stable EJ. Lung Cancer Mortality by County, Race and/or Ethnicity, and Sex in the United States, 2000-2019. Ann Am Thorac Soc. 2025 Nov;22(11):1774–1785.
Wu X, Heydorn KC, Kamat M, Garrett TJ, Dwyer JT, Thompson LD, Juraschek SP, Wambogo E, Pandey D, Pehrsson PR. Determination of Purine Contents in Commonly Consumed United States Foods: Updating the United States Department of Agriculture and Office of Dietary Supplements-National Institutes of Health Purine Database. J Nutr. 2025 Oct 29:S0022–3166(25)00683–2.
Collins-Bennett KA, Lacci-Reilly KR, Aguilar A, Fleg JL, George SM, Houmard JA, Huffman KM, Johannsen NM, Katz DH, Narendra J, Radom-Aizik S, Sparks LM, Xia A, Cooper DM. Accelerating the translation of findings from the MoTrPAC study to benefit clinical care: a qualitative analysis. BMC Prim Care. 2025 Oct 27;26(1):324.
Ansai N, Williams A, Emmerich SD, Herrick KA, Wambogo EA, Steele EM, Ogden CL. Ultraprocessed food consumption by urbanization level among United States youth and adults: cross-sectional analysis of NHANES 2013-March 2020. Am J Clin Nutr. 2025 Oct 17:S0002–9165(25)00614–8.
Couch CA, Williams AM, Stierman B, Storandt R, Leachman J, Mishra S, Juan W, Gahche JJ, Wambogo E, Mineva E, Pfeiffer CM, Ogden CL. Trends in vitamin D status in the United States, 2007-2023: a cross-sectional analysis of data from the National Health and Nutrition Examination Survey. Am J Clin Nutr. 2025 Oct 1:S0002–9165(25)00599–4.
Camargo JT, Machuca JO, Hinerman AS, Rodriquez EJ, Alvarez CS, Mensah GA, George SM, Bandiera F, Li Z, Sylte DO, Kelly YO, McHugh TA, Baumann MM, Celone M, Haile D, La Motte-Kerr W, Murray CJL, Dwyer-Lindgren L, Mokdad AH, Pérez-Stable EJ. Malnutrition Mortality Among Older Adults by County and Race and/or Ethnicity in the United States, 2000-2019. J Am Geriatr Soc. 2025 Sep;73(9):2868–2877.
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Funding Opportunities |
Application deadlines extended! The ODS Research Scholars Program supports emerging NIH intramural scientists to conduct research on the role of dietary supplements and/or their ingredients in health promotion and disease prevention. The purpose of the program is to foster long-term career interest in dietary supplement-related research and build future research capacity. Application deadlines for next year’s program have been extended, with final proposals due on February 13, 2026. |
ODS provides funding support to the NIH Institutes, Centers, and Offices (ICOs) through a co-funding program. Co-funding allows ODS to promote dietary supplement-related science by supporting NIH extramural dietary supplement-related research project grants, training and career development grants, and scientific conferences with primary ICOs. See the list of active ODS co-funding opportunities.
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News Around NIH |
Helene M. Langevin, M.D., Director of the National Center for Complementary and Integrative Health (NCCIH), retired from federal service on November 30, 2025. During her tenure at NCCIH, Dr. Langevin championed the advancement of whole person health, emphasizing integration across physiological systems and positive health processes such as resilience and restoration. She also led multiple NIH-wide initiatives that elevated whole person health as a central element of NIH’s emerging unified approach to reducing the burden of chronic disease in the United States. Read more about Dr. Langevin and her contributions to NIH from the NIH Director, Dr. Jay Bhattacharya.
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Science Shorts |
Numerous studies have examined the effects of omega-3 polyunsaturated fatty acids on the prevention of coronary heart disease (CHD). The findings from this research suggest that some people may benefit from omega-3 supplementation while others may not. In a recent publication in the European Journal of Epidemiology, Dr. Rikuta Hamaya and colleagues conducted a secondary analysis of the VITamin D and OmegA-3 TriaL (VITAL). VITAL was a randomized controlled trial, co-funded by ODS and other NIH Institutes and Centers, that examined the effects of omega-3s and vitamin D for the primary prevention of cardiovascular disease and cancer. In the new analysis, the researchers used a machine-learning approach to predict individual treatment effects of omega-3 supplementation on CHD risk using 11 pre-specified covariates, including race, diabetes status, baseline statin use, and fish consumption. From this, they developed an “omega-3 effect score” that could be used to guide clinical decision making.
Using data from 25,871 participants in VITAL, the researchers found that among the participants with an omega-3 effect score of 4 or higher, those who received omega-3 supplements had a lower 5-year CHD risk (2.5%) than those who received placebo (3.2%). Conversely, among participants with an omega-3 effect score that was less than 4, those who received omega-3 supplements had essentially the same 5-year CHD risk (1.4%) as those who received placebo (1.3%). These findings suggest that the omega-3 effect score could be a useful tool for stratifying individuals based on their expected benefit from omega-3 supplementation. However, external validation and additional randomized controlled trials are needed to fully understand the potential utility of this tool.
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Featured Fact Sheets |
 The ODS selenium fact sheet for health professionals has a fresh new format featuring concise summary sections that can be expanded to show more in-depth information. This essential resource provides clear, evidence-based information about the effectiveness, safety, and use of this vital nutrient.
Looking for general information? ODS also offers a selenium fact sheet for consumers in both English and Spanish. |
Also new! The probiotics fact sheet for consumers has been updated and includes a new section on necrotizing enterocolitis, which is a serious digestive tract illness that mostly affects preterm babies.
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About ODS
The Office of Dietary Supplements (ODS) is part of the National Institutes of Health (NIH), the nation’s medical research agency—supporting scientific studies that turn discovery into health. |
Contact Us
Office of Dietary Supplements National Institutes of Health 6705 Rockledge Drive
(Rockledge I) Room 730, MSC 7991 Bethesda, MD 20817
Email: [email protected]
Website: https://ods.od.nih.gov |
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