Principal Investigator: Guido F. Pauli, Ph.D.
Institution: University of Illinois at Chicago, Chicago, IL
The primary objective of CENAPT was to coordinate the curation and dissemination of good research practices and state-of-the-art technologies for research on natural products. These activities were pursued in coordination with the above-mentioned Center for High-throughput Functional Annotation of Natural Products. This center also pioneered the application of cutting-edge bioanalytical methodologies to botanicals, developed innovative approaches to the holistic characterization of the metabolomic complexity of natural products, and shared all of these efforts with the relevant research communities.
Highlighted Publications:
Bisson J, McAlpine JB, Friesen JB, Chen SN, Graham J, Pauli GF. Can invalid bioactives undermine natural product-based drug discovery?. J Med Chem. 2016;59(5):1671-1690. doi:10.1021/acs.jmedchem.5b01009
PubMedCentral: PMC4791574 [Open Access Article]
Established the concept of ubiquitous natural products that distract global natural products research by acting as Invalid/Improbable/Interfering Panaceas.
Kim SB, Bisson J, Friesen JB, Pauli GF, Simmler C. Selective chlorophyll removal method to "degreen" botanical extracts. J Nat Prod. 2020;83(6):1846-1858. doi:10.1021/acs.jnatprod.0c00005
First methodology for the systematic and reproducible removal of chlorophylls as interference/nuisance compounds in botanical extracts.
McAlpine JB, Chen SN, Kutateladze A, et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research [published correction appears in Nat Prod Rep. 2018 Nov 23;:]. Nat Prod Rep. 2019;36(1):35-107. doi:10.1039/c7np00064b. Raw Data [Dataverse]: dx.doi.org/10.7910/DVN/WB0DHJ
Developed groundbreaking rationales for the establishment of a repository of raw NMR data via coordination of a significant portion of the natural products research community.
Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential nedicinal chemistry of curcumin. J Med Chem. 2017;60(5):1620-1637. doi:10.1021/acs.jmedchem.6b00975
Provided a detailed set of rationales for the IMP nature of curcumin and the importance of distinguishing between crude plant materials and single constituents; most-read article of all time in the Journal of Medicinal Chemistry.
Sorkin B, Kuszak A, Fukagawa N, Hoffman F, Jafari M, Barrett B, Brown P, Bushman F,Chilton S, Coffey C, Ferruzzi M, Hopp C, Kiely M, Lakens D, MacMillan J, Meltzer D, Pahor M, Paul J, Pritchett-Corning K, Quinney S, Rehermann B, Setchell K, Sipes N, Stephens J, Taylor DL, Tiriac H, Walters M, Xi D, Zappalá G, Pauli G. Improving natural product research translation: From source to clinical trial. FASEB J. 2020;34(1):41-65. doi:10.1096/fj.201902143R
Comprehensive coordination and dissemination of translational factors that impact clinical trials with natural product interventions.