Center for High Content Functional Annotation of Natural Products: 2015-2020

Results in NIHReporter

Principal Investigators: John B. MacMillan, Ph.D., Roger G. Linington, Ph.D., and Michael A. White, Ph.D.
Institutions: University of Texas Southwestern Medical Center, Dallas, TX; Simon Fraser University, Burnaby, British Columbia, Canada: University of California Santa Cruz, Santa Cruz, CA

This team brought together experts in natural products chemistry, biological screening, data analytics, and bioinformatics. They developed innovative strategies to improve the speed, breadth, and precision and integration of the chemical and biological characterization of natural products in order to accelerate the understanding of the biological effects of natural products. The innovative approaches developed included cell-based, untargeted screening approaches to uncover bioactive molecules of interest and their corresponding molecular targets. A vital component of this Center was the dissemination of the methods developed to the greater scientific community.

Highlighted Publications

Kalwat MA, Hwang IH, Macho J, et al. Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. J Gen Physiol. 2018;150(12):1747-1757. doi:10.1085/jgp.201812177external link disclaimer PMCID: PMC6279362

McMillan EA, Kwon G, Clemenceau JR, et al. A genome-wide functional signature ontology map and applications to natural product mechanism of action discovery. Cell Chem Biol. 2019;26(10):1380-1392.e6. doi:10.1016/j.chembiol.2019.07.008external link disclaimer

van Santen JA, Jacob G, Singh AL, et al. The Natural Products Atlas: an open access knowledge base for microbial natural products discovery. ACS Cent Sci. 2019;5(11):1824-1833. doi:10.1021/acscentsci.9b00806external link disclaimer


 Prior CARBON Awards | NIH CARBON Program