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Dietary Supplement Analytical Methods and Reference Materials Program (AMRM)

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AMRM Program Areas

turmeric and turmeric powderAMRM is organized under three main program areas:

Analytical method development is generally funded through interagency agreements (IAG) with US Government entities such as US Food and Drug Administration (FDA) and the US Department of Agriculture (USDA). Botanical identification through chemical fingerprinting is funded through an IAG with USDA. Prior to 2012 the main approach to validating methods was through an IAG with FDA. The IAG funded FDA to expand and continue an existing method validation contract with AOAC International. The contract supported the development of Official Methods of Analysis SM (OMAs), and an infrastructure to support and stimulate the development and publication of methods. Based on the recommendations from the 2012 external expert review panel, the AMRM Program will now make a more direct leadership role in the selection of candidate methods for development and validation. In 2013, AOAC successfully competed for a five-year contract to develop and support stakeholder activities for the validation of analytical methods.

Reference materials are produced primarily by the National Institute of Standards and Technology (NIST).  NIST acquires materials and performs chemical analysis for pre-defined chemicals of interest using a standard NIST approach. When completed and available, the reference materials are accompanied by a Certificate of Analysis that lists the quantities of each measured constituent, along with a statement of the measurement uncertainty. When the amounts of constituents in a product can be verified by multiple techniques and multiple laboratories, NIST gives these certified reference materials the Standard Reference Material ®  (SRM) designation, indicating the material is a NIST certified reference material. NIST also produces calibration standard SRM. These are pure compounds or defined mixtures of pure compounds intended to be used to establish analyte identity and for instrument calibration.